Dimethyl Sulfoxide
Apexbio Technology LLC Rucaparib (free base) 283173-50-2 10mM (in 1mL DMSO)
Rucaparib (free base) (CAS 283173-50-2) also known as AG014699 or PF-01367338 is a pharmacological inhibitor targeting poly(ADP-ribose) polymerase (PARP) a nuclear enzyme centrally involved in DNA damage signaling and base excision repair pathways By impeding PARP activity Rucaparib compromises DNA repair capacity leading to persistent DNA strand breaks as evidenced by increased gamma-H2AX and p53BP1 foci It has demonstrated radiosensitizing properties in prostate cancer cells notably those harboring PTEN deficiency or expressing ETS gene fusion proteins due partly to inhibition of non-homologous end-joining (NHEJ) DNA repair Rucaparib serves as a tool compound in oncology research to study chemosensitization and radiosensitization strategies
Apexbio Technology LLC Vardenafil 224785-90-4 10mM (in 1mL DMSO)
Vardenafil (CAS 224785-90-4) is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5) It inhibits PDE5 enzyme activity with an IC50 of approximately 0 7 nM in vitro Compared with other PDE isoforms (PDE1-4 and PDE6) vardenafil demonstrates superior selectivity toward PDE5 though moderate inhibition of PDE6 (IC50 11 nM) is observed Vardenafil enhances cGMP accumulation in human corpus cavernosum and significantly potentiates nitric oxide (SNP)- acetylcholine- and electrical field stimulation-induced relaxation in human trabecular smooth muscle Its vasodilatory effects render it suitable for research in erectile function and related vascular physiology
Apexbio Technology LLC Chlorocresol 10mM (in 1mL DMSO)
B1696 is a small molecule compound utilized in biomedical research primarily due to its modulatory effects on specific cellular signaling pathways Although the explicit molecular target is currently unpublished available evidence indicates that B1696 influences cellular processes implicated in inflammation immune response and cell proliferation Researchers employ this compound to investigate disease mechanisms and signaling networks within in vitro or ex vivo experimental systems contributing valuable information on therapeutic intervention strategies and drug development efforts
Apexbio Technology LLC SRT1720 HCl 1001645-58-4 10mM (in 1mL DMSO)
SRT1720 HCl is a small molecule activator of SIRT1 exerting more potent activation than resveratrol It functions through a SIRT1- and PGC-1 -dependent mechanism modulating mitochondrial oxidative metabolism and insulin sensitivity The compound has demonstrated activity in regulating cell growth and apoptosis in multiple myeloma (MM) cells without notably affecting normal cell viability Its antitumor properties relate to activation of caspase-8 caspase-9 caspase-3 and PARP enhancement of reactive oxygen species generation induction of ATM/CHK2 signaling suppression of NF- B signaling and reduction of VEGF-induced migration SRT1720 is utilized in biomedical research to investigate metabolic pathways tumor biology and potential sensitization effects to chemotherapy agents
Apexbio Technology LLC PTC-209 315704-66-6 10mM (in 1mL DMSO)
PTC-209 (CAS 315704-66-6) is a small-molecule inhibitor targeting BMI-1 identified through Gene Expression Modulation by Small molecules (GEMS) technology It acts by suppressing BMI-1 expression at the transcriptional level displaying an IC50 of approximately 0 5 M In HCT116 cells PTC-209 reduces both UTR-mediated and endogenous BMI-1 expression It selectively restricts cell proliferation in certain tumor and stem cell types including U937 HT1080 and human hematopoietic stem cells without affecting viability in cell lines such as HEK293 and HT1080 Thus PTC-209 is primarily utilized in studies exploring cancer stem cell growth and oncogenesis involving BMI-1 and the PRC1 complex
Apexbio Technology LLC Eptifibatide 188627-80-7 10mM (in 1mL DMSO)
Eptifibatide is a cyclic heptapeptide belonging to the glycoprotein IIb/IIIa inhibitor category functioning as an antagonist of platelet adhesion by reversibly binding to the platelet glycoprotein IIb/IIIa receptor This receptor located on platelet surfaces mediates platelet aggregation through binding fibrinogen and von Willebrand factor processes essential in thrombus formation By blocking the GP IIb/IIIa receptor binding site Eptifibatide inhibits fibrinogen-dependent platelet cross-linking reducing platelet aggregation In biomedical research Eptifibatide serves as a pharmacological tool to investigate platelet function thrombosis mechanisms and related cardiovascular diseases in preclinical and clinical models
Apexbio Technology LLC AZD6482 1173900-33-8 10mM (in 1mL DMSO)
AZD6482 (CAS 1173900-33-8) is a selective ATP-competitive inhibitor of phosphoinositide 3-kinase beta (PI3K ) It exhibits inhibitory potency with IC50 values of 0 69 nM for PI3K compared to 13 6 nM for PI3K 47 8 nM for PI3K and 136 nM for PI3K In vitro AZD6482 reduces insulin-induced glucose uptake in human adipocytes (IC50 of 4 4 M) Preclinical studies in dogs indicate anti-thrombotic activity without elevating bleeding risks Clinical evaluation showed good tolerability in human volunteers with modest effects on insulin sensitivity parameters AZD6482 serves as a valuable tool to investigate PI3K function in platelet biology and metabolic regulation
Apexbio Technology LLC Probenecid 57-66-9 10mM (in 1mL DMSO)
Probenecid is an inhibitor targeting organic anion transporters multidrug resistance-associated proteins (MRPs) and pannexin-1 channels showing an IC50 of 150 M for pannexin-1 inhibition MRPs a class of ATP-binding cassette (ABC) transporters mediate efflux of diverse molecules across cellular membranes contributing to drug resistance Probenecid counteracts MRP-mediated drug resistance in multidrug-resistant tumor cell lines enhancing cellular sensitivity to chemotherapeutic agents like daunorubicin and vincristine In animal research Probenecid protects neurons against ischemia/reperfusion-induced injury suppressing inflammation-associated enzyme activity and reducing glial cell activation
Apexbio Technology LLC Batimastat (BB-94)(Synonyms: BB-94, Batimastat, MMP inhibitor BB-94), 10mM (in 1mL DMSO), CAS: 130370-60-4.
Batimastat (BB-94 CAS 130370-60-4) is a synthetic small-molecule inhibitor targeting matrix metalloproteinases (MMPs) Structurally a polypeptide-like analogue of collagen substrates batimastat contains a peptidic backbone and a hydroxamate moiety that binds the catalytic zinc atom of MMPs It inhibits several MMP subtypes markedly including MMP-1 MMP-2 MMP-3 MMP-7 and MMP-9 with reported IC50 values of 3 4 20 6 and 4 nM respectively In preclinical studies batimastat demonstrates inhibitory effects on tumor growth and angiogenesis across various tumor models including ovarian and colon carcinoma xenografts making it relevant for cancer research and therapeutic development
Apexbio Technology LLC Epoxomicin 134381-21-8 10mM (in 1mL DMSO)
Epoxomicin (CAS 134381-21-8) is a naturally occurring proteasome inhibitor initially isolated from actinomycete cultures It acts primarily by forming covalent bonds through its -epoxyketone moiety with catalytic residues of the proteasome resulting in potent inhibition of the chymotrypsin-like (CTRL) activity of the 20S proteasome subunit Epoxomicin also inhibits proteasomal trypsin-like and peptidyl-glutamyl peptide hydrolysis activities albeit at significantly lower rates It exhibits anti-inflammatory and antitumor activities and is employed experimentally to study ubiquitin-proteasome-mediated cellular pathways bone formation regulation and Parkinson s disease model generation
Apexbio Technology LLC Meropenem 96036-03-2 10mM (in 1mL DMSO)
Meropenem is a broad-spectrum -lactam antibiotic within the carbapenem subclass characterized by bactericidal activity against both gram-positive and gram-negative organisms It primarily acts by binding to penicillin-binding proteins (PBPs) mainly PBP2 of Escherichia coli and Pseudomonas aeruginosa and PBP1 of Staphylococcus aureus thus disrupting cell wall synthesis and bacterial growth In vitro studies indicate Meropenem inhibition is effective at MIC 4 mg/L (susceptible strains) intermediate at 8 mg/L and resistant at 16 mg/L Meropenem demonstrates greater potency against gram-negative bacteria compared to Imipenem with typical IC50 values around 0 25 mg/L for anaerobic strains It is typically used in microbiological research to investigate antibiotic susceptibility bacterial resistance mechanisms and interactions with drug metabolism
Apexbio Technology LLC Meptazinol HCl 59263-76-2 10mM (in 1mL DMSO)
Meptazinol HCl also chemically known as WY-22811 hydrochloride is a centrally acting analgesic agent characterized as a partial agonist at the 1 opioid receptor Structurally it belongs to the synthetic opioid family and interacts selectively with opioid receptors in the central nervous system to modulate pain transmission Its partial agonist properties allow for analgesic activity with generally reduced risk of respiratory depression compared to full opioid agonists making it a useful compound in pharmacological studies examining opioid receptor activation modulation and analgesic effects In biomedical research settings Meptazinol HCl is commonly employed to investigate pain management mechanisms opioid receptor signaling pathways receptor selectivity profiles and analgesia-related side effect mitigation
Apexbio Technology LLC KPT-185 1333151-73-7 10mM (in 1mL DMSO)
KPT-185 (CAS 1333151-73-7) is an irreversible selective inhibitor of chromosome region maintenance 1 (CRM1) a nuclear export receptor essential for nuclear-cytoplasmic transport KPT-185 binds covalently at Cys528 of CRM1 thereby inhibiting CRM1-mediated nuclear export of tumor suppressor proteins Studies demonstrate that KPT-185 impairs proliferation and colony formation in acute myeloid leukemia (AML) cell lines exhibiting IC50 values ranging from 100 500 nM inducing G1 cell cycle arrest apoptosis and differentiation of AML blasts Additionally KPT-185 reduces growth and promotes apoptosis in pancreatic cancer models (Colo-357 HPAC BxPC-3) highlighting its potential in cancer research